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Oxidative stress and GPX2 control pancreatic vs. non-pancreatic cell fate in human endoderm | Nature Communications

The expression of fatty acid synthase (FASN), a key enzyme essential for the FAS, is elevated in breast cancer ( FASN gene is upregulated due to the arousal of AKT and SREBP-1 in breast tumor cells ( Overview of Metastasis in Breast Cancer Tumor metastasis is a sequential multi-step process, which includes local invasion, intravasation, migration through the lymphatics or blood vessels, extravasation and colonization giving rise to the formation of metastases in distant organs ( The Process of Metastasis The step one of the metastasis is that tumor cells break away from the tumor bed and migrate from the stroma into the bloodstream ( After escaping from the original tumor site to blood circulation, breast tumor cells begin to migrate to remote organs

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This persists even when chemotherapy is combined with targeted agents and immunotherapy in the recurrent and metastatic settings [1,5]