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The condition is characterized by the “dying back” of distal sensory axons in a length-dependent manner, presenting as a “stocking and glove” pattern of sensory loss
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Specifically, CLP-induced systemic inflammation may activate microglia to secrete pro-inflammatory mediators, which suppress the Nrf2/HO-1/GPX4 redox axis, triggering mitochondrial dysfunction and oxidative stress
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