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Indeed, administration of B12 has been shown to alter DNA methylation patterns in patients [160]

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This article provides a detailed description of three prior reports to the European Medicines Agency (reports 24,570, 24,571, and 47,402) which, together, according to the authors, “confirm that the recommended standard paracetamol dose of 10 to 15 mg/kg is a safe and effective dose for use in pediatric patients when administered as a single dose or as multiple doses for up to 72 h.” However, the only safety measure used in the three studies was ALT levels as a marker for liver function, assessed for a maximum of 72 h