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19 Gene expression differences involved in O-GlcNAcylation and hexosamine biosynthesis pathway have also been detected between diabetic and nondiabetic individuals, 20 probably because multiple molecules in insulin signaling pathways can be modified by glycosylation which in turn reduces phosphorylation, leading to inhibition of insulin signaling

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Given the role of serotonin in affective illness, it is not surprising that selective serotonin reuptake inhibitors (SSRIs) have been the focus of treatment for alcohol dependence and comorbid depression (Pettinati et al., 2010), anxiety (Book et al., 2008), and posttraumatic stress disorder (Petrakis et al., 2012)