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A single peptide is often the more rigorous choice when the aim is to measure one clean effect, since any change can then be attributed to it with confidence, while a combination makes more sense when the question spans several pathways and the interactions between them are part of what is being studied
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We hypothesized that the proteome of the viruses should preferentially interact with enzymes relevant to their replication without harming cellular viability and hence, be considered tier-1 targets
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