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[18] Another proapoptotic mediator of beta cells during ER stress and mitochondrial oxidative stress is the p53 upregulated modulator of apoptosis (PUMA), a member of the Bcl-2 homolog3r domain only proteins (BH3)-only branch of the B-cell lymphoma-2 (Bcl-2) protein family

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These encompass the maintenance of iron homeostasis, the metabolic process of cysteine, the activity of GPX4, the synthesis of polyunsaturated fatty acids (PUFA), the regulatory role of nuclear factor E2-related factor (NRF2), the function of the tumor suppressor protein p53, the protective mechanism of heat shock proteins (HSPs), the regulatory role of iron regulatory inhibitor-1 (FSP1), the activation state of AMP-activated protein kinase (AMPK), and the supply of nicotinamide adenine dinucleotide phosphate (NADPH)