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Since 10% of ME/CFS patients have these alleles, their risk is altered around 1.5-2.0-fold, meaning genetic differences in the immune system may change the risk of developing ME/CFS (89)
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The Institute of Medicine reports that "no adverse effects have been associated with excess vitamin B12 intake from food and supplements in healthy individuals." However, if you're not deficient in vitamin B12 to begin with or you don't address the underlying reasons you might be deficient, injections likely won't do much to improve overall quality of life
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