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506 SIRT3 promotes autophagy in Ang II-induced myocardial hypertrophy via deacetylation of FoxO1, 507 blocks the cardiac hypertrophic response by augmenting FoxO3a-dependent antioxidant defense mechanisms in mice, 164 and exerts protective effects against cardiac hypertrophy by reducing the level of acetylation and activity of poly (ADP-ribose) polymerase-1
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