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This results in excessive release of dopamine, norepinephrine, and serotonin, which overstimulate postsynaptic receptors and produce the euphoric and stimulant effects associated with METH use (Lee et al., 2009
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In addition, we observe higher levels of malondialdehyde (MDA), protein carbonyls and 8-hydroguanosine (8-OHdG) DNA adduct, as hallmarks of cellular lipid, protein and DNA oxidative damage, respectively
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