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However, excessive glutamate in synaptic cleft may lead to calcium overload by overactivating NMDA receptors or non‐NMDA receptors (including AMPA receptors and kainic acid (KA) receptors) which generate large amounts of ROS and lead to neurotoxicity.107 Astrocytes are the main cells to maintain homeostasis of glutamate which indirectly affect the balance of oxidative stress (Figure 2)
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