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7 Further to this, teclistamab and talquetamab (T-cell engagers that target MM antigens and the CD3 subunit of T-cell receptors) are being investigated in combination with daratumumab for RRMM in a phase Ib trial (TRIMM-2)
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In ARMS, JNK1 levels are diminished by the PAX3-FKHR oncoprotein, thereby leaving other pathways open to modulating or inducing c-Jun phosphorylation and accelerating cell proliferation
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