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The γ-glutamate-cysteine ligase promoter contains potential cis-acting elements, including consensus recognition sites for binding of different transcription factors such as: activator protein-1 and -2 (AP-1 and AP-2), Sp-1, NF-kB, and electrophile responsive element (ARE) containing an embedded phorbol myristate acetate-responsive element (TRE/AP-1) [94]
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Inhibition of TGR was shown in biochemical assays with recombinant protein, and in ex vivo worms by measurement of both TGR-generated fluorescent products from TRFS-Green and the decrease in the GSH/GSSG ratio
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