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The Snell dwarf mouse serves as a valuable tool for understanding the GH–IGF-1 axis, as studies have demonstrated that the lack of Pit-1 results in decreased GH and IGF-1 production, leading to the dwarfism phenotype

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Evidence (CD22-targeted CAR T-cell therapy): Investigators at the NCI reported a phase I/II trial of 58 children and young adults treated with a CD22-targeted CAR T-cell approach.[207][Level of evidence C2] Of the 55 patients with ALL who were infused, 40 achieved CRs (73%)