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For instance, MMP-3 promotes EMT by activating Wnt/Ξ²-catenin and TGF-Ξ² signaling pathways, while simultaneously inducing fibroblast proliferation and collagen deposition, as demonstrated by reduced fibrosis in MMP-3-knockout mice following bleomycin challenge (Pardo et al., 2016
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In that process, proliferating chondrocytes predominantly express Sox9 and type II collagen and then differentiate into hypertrophic chondrocytes that express Runx2, MMP13 and type X collagen 39
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