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Moreover, SQSTM1 acts in coordination with TRAF6 (TNF receptor associated factor 6) in the K63-linked ubiquitination of mTOR, which is also involved in regulating lysosomal translocation of mTORC1 (Linares et al., 2013)
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This close correlation of CBF and CMR glc (and, to a lesser extent, the cerebral metabolic rate of oxygen, CMR O2 ) demands highly dynamic and fine-tuned mechanisms to adapt local glucose and oxygen delivery and carbon dioxide removal via the blood to the actual demand of active brain regions
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