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Together, these findings define an ischemia-dominant metabolic phenotype in neonatal HIBI and nominate mitochondrial function, NAD⁺ metabolism, neurotransmitter regulation, and arginine-NO pathways as biologically plausible targets for future therapeutic strategies aimed at preserving bioenergetic stability and limiting secondary neuronal injury
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11 This entity is distinguished from other heavily pigmented melanocytic neoplasms, including pigmented epithelioid melanocytoma and melanoma, by the presence of these specific monosomies and a lack of additional genomic alterations ( TERT promoter, CDKN2A gene mutations, etc) encountered in melanoma
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