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Acknowledgements Funding for this study was provided by the National Natural Science Foundation of China (82388101, 22375127), the Shanghai Commission for Science and Technology (Grant No

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Titles Ensign Professor of Medicine (Digestive Diseases) Emeritus Director, Yale Liver Center Education & Training FellowYale School of Medicine (1969) ResidentNew York Hospital (1964) MDJohns Hopkins University (1962) ABHaverford College, Biology (1958) Additional Information Emeritus Director, Yale Liver Center: (2020) International Recognition Award: European Association for the Study of Liver Disease (2019) Johns Hopkins Society of Scholars -2016: Johns Hopkins University (2016) Spinoza Profesesorship: University of Amsterdam, the Netherlands (2009) NIH MERIT Award: National Institutes of Health (2008) Distinguished Scientific Achievement Award: American Liver foundation (1999) Distinguished Achievement Award: American Association for the Study of the Liver (1998) Ismar-Boas Medal: German Society of Gastroenterology and Metabolism (1996) Ensign Professorship: Yale University (1996) Distinguished Achievement Award: American Gastroenterology Association (1989) AB of Internal Medicine, Internal Medicine (1969) Haverford College (2009 - 2021): Board Member Mt Desert Island Biological Laboratory (1995 - Present): Board Member American Liver Foundation (1976 - Present): voluntary health agency Yale University School of Medicine: Committee Member Maxwell M, Deng Y, Chen B, Silveira M, Boyer J , Assis D