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In mice with acute lymphocytic choriomeningitis virus, CD4+ T cells with the silence of mechanistic target of rapamycin complex-2 (mTORC2) impede the formation and growth of memory CD4+ T cells, which is attributed to the IL-7-activated mTORC2–AKT–GSK3 signaling pathway, leading to excessive GPX4 peroxidase and suppression of ferroptosis in memory cells (98)
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