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An increased intestinal PEG-400 permeability in first-degree healthy relatives of Crohn's disease patients was described for the first time in 1986 ( in vivo studies also show that the L/rhamnose ratio was restored with the induction of remission with an elemental diet in patients with active CD ( 51 Cr-EDTA was normalized by an anti-TNF-α therapy ( The first study ex vivo in Ussing chambers (1999) evaluating the epithelial barrier function in colonic tissue from UC patients with mild or moderate macroscopic disease activity showed a 50% decrease of the total electrical wall resistance (assessed by transmural impedance analysis) when compared to healthy subjects
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