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[12] Beyond that specific episode, GH secretagogues generally can affect glucose metabolism and insulin sensitivity: raising GH tends to oppose insulin action, and studies of oral ghrelin-mimetic secretagogues in older adults have documented measurable effects on glucose handling alongside their GH and IGF-I elevation

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These results suggest that Ipamorelin may exhibit a relatively short half-life, estimated at approximately 2 hours, with diminishing effects thereafter