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Costain G, Ghosh MC, Maio N, Carnevale A, Si YC, Rouault TA, et al
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In preclinical cell models, KPV has been reported to inhibit NF-kB and MAP-kinase signaling at nanomolar concentrations and to lower pro-inflammatory cytokine output in intestinal and epithelial cells, as described in work dissecting the anti-inflammatory effect of the KPV alpha-MSH fragment
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