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Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, as they reflect whether side effects are bothersome enough to outweigh potential benefits

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The patient is either receiving guideline-directed medical therapy (GDMT) for cardiovascular disease or has a documented clinical reason for not receiving it (such as a contraindication to lipid-lowering agents, antiplatelets, beta-blockers, or renin-angiotensin inhibitors) ( Documentation is required for approval) Continuation of therapy: The request is for continued treatment, and