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“IGF-1 plays a central role in tumor development by stimulating proliferation and inhibiting apoptosis in cancer cells.” — Pollak, Nature Reviews Cancer → Acromegaly-Like Symptoms (Rare) In extremely high or prolonged doses—especially when stacked with HGH—IGF-1 may contribute to: Bone thickening (jaw, forehead, hands) Enlarged soft tissue Headaches or carpal tunnel symptoms These side effects mimic acromegaly , a condition caused by excessive GH/IGF-1 signaling
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