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You've probably heard of MTHFR, but methylation is much bigger than one gene. It's a foundational process running in every cell, quietly transferring tiny chemical tags (through SAMe, your body's main methyl

Symptom scores were stable in both groups during this phase, indicating 45 days of a very-low-carbohydrate ketogenic diet followed by 45 days of a low-glycemic and insulinemic diet had a lasting benefit that could not be achieved by 90 days on a low-glycemic and insulinemic diet

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In mouse models of high‑fat diet‑induced liver steatosis, it significantly inhibits hepatic NNMT activity, reduces NAM methylation, increases NAD+ and SAM levels, enhances mitochondrial fatty acid oxidation, reduces hepatic triglyceride and lipid accumulation, lowers lipotoxicity markers (e.g., malondialdehyde, transaminases), improves hepatocellular injury, and reverses steatosis

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