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Whereas, NR2 receptors increase the influx of Ca 2+ ions upon glutamate binding, which in turn activates downstream signaling mechanisms involving protein kinase A (PKA) and CAMKII [17]
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Hx-heme complexes are internalized via the scavenger receptor LDL receptor-related protein 1/CD91 (Hvidberg et al., 2005) mainly by hepatocytes and macrophages (Figure 1) (Herz and Strickland, 2001)
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