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The timing, frequency, and extent of senescent cell removal remain open questions (for example, “when is it best to clear them?” “What is the rebound or regenerative consequence?”)

50 days

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Both of these enzymes are redox sensitive and under inflammatory conditions are impaired (particularly in the presence of free iron), thus interfering with glutamate homeostasis.[6,141] Also at play is the cysteine-glutamate antiporter (system X c - ), which exchanges extracellular cystine for intracellular glutamate, which under pathological conditions can raise extraneuronal glutamate levels and induce excitotoxicity.[37] Normally, this exchange system is essential for generating astrocytic glutathione from cystine, which when assembled, is then transferred to the neuron